ProjectOrthoGenx's Next Generation Orthopedic Implants

Current medical implants bear several critical issues, including biocompatibility, inflammation, pain, stress shielding, and sustainability. In addition, ion deposition from these implants can lead to various neurodegenerative diseases, posing significant health risks to patients. The medical community has explored Hydroxyapatite (HA) coated implants to mitigate the challenges posed by traditional implants. HA, a naturally occurring mineral form of calcium apatite, aims to enhance biocompatibility. This increased biocompatibility stems from our body's recognition of HA since the compound is found in our bones. However, despite its promise, HA coatings are not without their limitations, notably stress shielding. This phenomenon occurs when the implant absorbs too much mechanical load, leading to the weakening of the surrounding bone tissue. Our project seeks to overcome these limitations by developing full-density HA implants. These implants distinguish themselves through superior biocompatibility, sustainability, and patient comfort. Unlike traditional implants, full-density HA implants possess the remarkable ability to self-repair through remineralization. Remineralization occurs through calcium deposition driven by our body. The capability to self-repair increases the quality of life for the patient, as well as improves the strength of the implant. Remineralization thus also reduces the chances of massive fractures, as small cracks are fixed quickly, ensuring the implant does not weaken. A remarkably promising aspect of full-density HA implants is their potential for future advancements. By infusing these implants with microdoses of specific minerals and chemicals (such as magnesium and copper), we aim to enhance their osseointegration—the process by which the implant integrates with bone tissue. This enhancement could result in implants that not only integrate more effectively but also alleviate pain and reduce adverse symptoms for patients. Due to HA implants' inherent osteocompatibility, osseointegration properties, and self-repair capabilities, the implant seamlessly integrates with the existing bone, gradually becoming a part of the patient’s natural skeletal structure. Over time, the infused minerals and chemicals support the body’s natural processes, strengthening the bone and mitigating pain, inflammation, and other complications. In summary, our project on full-density Hydroxyapatite implants signifies a major advancement in the quest for improved and sustainable medical implants. By addressing the limitations of traditional implants and introducing a solution that enhances biocompatibility, reduces pain, and supports long-term patient health, we are paving the way for a transformative future in medical implant technology.

I am currently an IB Diploma Candidate with expertise in additive manufacturing and material science. My research focuses on analyzing biological interactions between cells and hydroxyapatite. I can support other organizations by offering insights into advanced manufacturing techniques, material properties, and biocompatibility studies, particularly in the context of biomedical applications.